Diabetes, a high BMI, high glycated haemoglobin, and elevated serum IL-6 levels have all been linked to poor outcomes in COVID-19 infection. Rising levels of several cytokines, particularly IL-6, are among the immunopathological mechanisms of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The latter is linked to hyperglycemia and insulin resistance and may be useful in predicting the onset of GDM. MedDiet, which is high in omega-3 polyunsaturated fatty acids, vitamins, and minerals, boosts the immune system and may modulate IL-6, C reactive protein, and Nuclear Factor (NF)-B. 

Following the MedDiet before and during pregnancy may have a protective effect, lowering GWG and the risk of GDM while also improving immune response to viral infections like COVID-19.