This article is based on Cross-sectional study and is done via web survey. To compare the frequencies of physical activity status with sociodemographic variables, a multinomial logistic and a multiple logistic regression for habitual ultra-processed foods was performed. The first evidence of physical activity habits’ modifications in adolescents during Covid-19 confinement in two countries in Europe and three countries in Latin America. Despite the different determinants of physical inactivity in the population in both continents, The observation shows a fairly high percentage of physical inactivity in the population before and during the Covid-19 pandemic, which was worsened during the lockdown measures. Factors such as country economic development and income inequality are noted in highly cited studies as being determinants of adolescent health. The change in physical activity status was greater in Latin American countries. In addition, the observation shows high frequency of ultra-processed foods consumption among adolescents, which was also worsened by the lockdown. Again, Latin American countries exhibited higher habitual ultra-processed food consumption. These findings reinforce the importance of developing public health policies for this group, focusing on measures to encourage a healthy lifestyle (diet and exercise), especially during and after periods of social isolation.