In this report, an update on the evidence of the contribution of nutritional factors as immune-enhancing aspects, factors that could reduce their bioavailability, and the role of the optimal status of these nutrients within the COVID-19 pandemic context was carried out. Nutritional factors are vitamins (D, A, C, Folate, B6 and B12) and minerals (zinc, iron, selenium and copper) by The highest European authority in food safety, EFSA. The results of this ecological study show that the suboptimal consumption of Vitamin D, Vitamin C, Vitamin B12, and iron is correlated with either COVID-19 incidence or mortality indicators. Thus, the body of evidence suggests conducting epidemiological scientific studies, intervention studies, and/or in vitro approaches in order to establish and characterize the benefits of Vitamin D and iron (or even their combination) against COVID-19.So, both suboptimal intake and genetic risk of suboptimal status should be screened, and consequent nutrigenetic strategies must be put in place to help individuals to reach an optimal nutritional state and, consequently, improve the whole population’s immunity to face this pandemic.
